GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer
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- 作者：Jiangning Gua ; b ; c ; 1 ; Di Wangd ; 1 ; Jiaqiang Zhanga ; c ; Yi Zhua ; e ; Ying Lib ; Hao Chena ; c ; Minmin Shic ; Xuelong Wangb ; Baiyong Shena ; c ; Xiaxing Denga ; c ; Qian Zhana ; c ; Gang Weib ; weigang@picb.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Chenghong Penga ; c ; chhpeng@188.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：GFRα2 ; PTEN ; Mir-17-5p ; Chemoresistance ; Pancreatic cancer
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：380
- 期：2
- 页码：434-441
- 全文大小：2485 K
文摘
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To validate the correlation between GFRα2 and PTEN in pancreatic cancer.
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A new mechanism of Mir-17-5p in pancreatic cancer.
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GFRα2/Mir-17-5p/PTEN axis plays an important role in both tumor growth and chemoresistance in pancreatic cancer.