Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response and epithelial-mesenchymal transition in mice
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- 作者：Zhu-Xia Tana ; 1 ; Yuan-Hua Chenb ; c ; 1 ; Shen Xua ; Hou-Ying Qina ; Cheng Zhangb ; Hui Zhaoa ; zhaohuichenxi@126.com" class="auth_mail" title="E-mail the corresponding author ; De-Xiang Xub ; xudex@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Calcitriol ; Bleomycin ; Inflammation ; Nuclear factor kappa B p65 ; Epithelial&ndash ; mesenchymal transition ; Lung ; Mice
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：240
- 期：1
- 页码：161-171
- 全文大小：4967 K
文摘
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Calcitriol attenuates BLM-induced inflammatory cytokines in the lungs.
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Calcitriol inhibits BLM-activated NF-κB signaling in the lungs.
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Calcitriol inhibits BLM-activated PI3K/Akt and p38 MAPK in the lungs.
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Calcitriol inhibits BLM-induced EMT in the lungs.
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Calcitriol inhibits BLM-activated TGF-β-Smad signaling in the lungs.