Calcitriol inhibits tumor necrosis factor alpha and macrophage inflammatory protein-2 during lipopolysaccharide-induced acute lung injury in mice
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- 作者：Zhu-Xia Tana ; 1 ; Yuan-Hua Chenb ; c ; 1 ; Shen Xua ; Hou-Ying Qina ; Hua Wangb ; Cheng Zhangb ; De-Xiang Xub ; xudex@126.com" class="auth_mail" title="E-mail the corresponding author ; Hui Zhaoa ; zhaohuichenxi@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARDS ; acute respiratory distress syndrome ; CYP ; cytochrome P450 ; ELISA ; enzyme linked immunosorbent assay ; LPS ; lipopolysaccharide ; MAPK ; mitogen-activated protein kinase ; MIP-2 ; macrophage inflammatory protein-2 ; NF-κB ; nuclear factor kappa B ; TLR ; toll-like receptor ; TNF-α ; tumor necrosis factor alpha ; VDR ; vitamin D receptor ; VitD3 ; vitamin D3
- 刊名：Steroids
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：112
- 期：Complete
- 页码：81-87
- 全文大小：2530 K
文摘
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Calcitriol protects mice from LPS-induced acute lung injury.
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Calcitriol attenuated LPS-induced elevation of TNF-α and MIP-2 in sera and lung.
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Calcitriol inhibits LPS-activated PI3K/Akt signaling pathways in the lung.
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Calcitriol inhibits LPS-activated p38 MAPK signaling pathways in the lung.
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Calcitriol inhibits LPS-activated NF-κB signaling pathways in the lung.