G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis
详细信息 查看全文
- 作者：Tao Weia ; 1 ; Wei Chena ; 1 ; Liang Wena ; Jian Zhanga ; Qi Zhanga ; Jiaqi Yanga ; Hao Liua ; Bryan Wei Chena ; Yue Zhoua ; Xinhua Fengb ; Qi Yangc ; Xueli Baia ; shirleybai57@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Tingbo Lianga ; d ; liangtingbo@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：GPER ; Hepatocellular carcinoma ; Inflammation ; Interleukin-6
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 November 2016
- 年：2016
- 卷：382
- 期：2
- 页码：195-202
- 全文大小：2494 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
G-protein coupled estrogen receptor (GPER) expression is significantly downregulated in hepatocellular carcinoma.
- class="label">•
GPER knockout mice exhibited accelerated liver tumorigenesis in chemical-induced tumor model with enhanced inflammation.
- class="label">•
GPER is not directly associated with tumor cell growth, but can moderate macrophages and hepatic stellate cells.