Relationship of sitting time and physical activity with non-alcoholic fatty liver disease

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• 作者：Seungho Ryu¹ ; ² ; ³ ; ^{sh703.yoo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yoosoo Chang¹ ; ² ; ³ ; ^{yoosoo.chang@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hyun-Suk Jung² ; Kyung Eun Yun² ; Min-Jung Kwon² ; ⁴ ; Yuni Choi² ; Chan-Won Kim² ; Juhee Cho² ; ³ ; Byung-Seong Suh² ; Yong Kyun Cho⁵ ; Eun Chul Chung² ; ⁶ ; Hocheol Shin² ; ⁷ ; Yeon Soo Kim⁸
• 关键词：BMI ; body mass index ; CI ; confidence interval ; CVD ; cardiovascular disease ; FLI ; fatty liver index ; HEPA ; health-enhancing physically active ; HOMA-IR ; homeostasis model assessment of insulin resistance ; HDL-C ; high-density lipoprotein-cholesterol ; LDL-C ; low-density lipoprotein-cholesterol ; NAFLD ; non-alcoholic fatty liver disease ; SMI ; skeletal muscle mass
• 刊名：Journal of Hepatology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：63
• 期：5
• 页码：1229-1237
• 全文大小：812 K

文摘

The goal of this study was to examine the association of sitting time and physical activity level with non-alcoholic fatty liver disease (NAFLD) in Korean men and women and to explore whether any observed associations were mediated by adiposity.

Methods

A cross-sectional study was performed on 139,056 Koreans, who underwent a health examination between March 2011 and December 2013. Physical activity level and sitting time were assessed using the validated Korean version of the international Physical Activity Questionnaire Short Form. The presence of fatty liver was determined using ultrasonographic findings. Poisson regression models with robust variance were used to evaluate the association of sitting time and physical activity level with NAFLD.

Results

Of the 139,056 subjects, 39,257 had NAFLD. In a multivariable-adjusted model, both prolonged sitting time and decreased physical activity level were independently associated with increasing prevalence of NAFLD. The prevalence ratios (95% CIs) for NAFLD comparing 5–9 and 猢?0 h/day sitting time to <5 h/day were 1.04 (1.02–1.07) and 1.09 (1.06–1.11), respectively (p for trend <0.001). These associations were still observed in subjects with BMI <23 kg/m². The prevalence ratios (95% CIs) for NAFLD comparing minimally active and health-enhancing physically active groups to the inactive group were 0.94 (0.92–0.95) and 0.80 (0.78–0.82), respectively (p for trend <0.001).

Conclusions

Prolonged sitting time and decreased physical activity level were positively associated with the prevalence of NAFLD in a large sample of middle-aged Koreans, supporting the importance of reducing time spent sitting in addition to promoting physical activity.