Sugar-sweetened carbonated beverage consumption and coronary artery calcification in asymptomatic men and women

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• 作者：Sohyun Chun ; MD^a ; ^b ; ^m ; Yuni Choi ; BS^a ; ^m ; Yoosoo Chang ; MD ; PhD^a ; ^c ; ^d ; ^{yoosoo.chang@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Juhee Cho ; PhD^a ; ^d ; ^e ; ^f ; ^g ; Yiyi Zhang ; PhD^e ; ^f ; ^g ; Sanjay Rampal ; MD^e ; ^f ; ^g ; ^h ; Di Zhao ; MHS^e ; ^f ; ^g ; Jiin Ahn ; MSPH^a ; Byung-Seong Suh ; MD ; PhD^c ; Roberto Pastor-Barriuso ; PhDⁱ ; Joao A.C. Lima ; MD^j ; Eun Chul Chung ; MD ; PhD^b ; ^k ; Hocheol Shin ; MD ; PhD^a ; ^l ; Eliseo Guallar ; MD ; DrPH^e ; ^f ; ^g ; Seungho Ryu ; MD ; PhD^a ; ^c ; ^d ; ^{sh703.yoo@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 刊名：American Heart Journal
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：177
• 期：Complete
• 页码：17-24
• 全文大小：354 K

文摘

Sugar-sweetened carbonated beverage consumption has been linked to obesity, metabolic syndrome, type 2 diabetes, and clinically manifest coronary heart disease, but its association with subclinical coronary heart disease remains unclear. We investigated the relationship between sugar-sweetened carbonated beverage consumption and coronary artery calcium (CAC) in a large study of asymptomatic men and women.

Methods

This was a cross-sectional study of 22,210 adult men and women who underwent a comprehensive health screening examination between 2011 and 2013 (median age 40 years). Sugar-sweetened carbonated beverage consumption was assessed using a validated food frequency questionnaire, and CAC was measured by cardiac computed tomography. Multivariable-adjusted CAC score ratios and 95% CIs were estimated from robust Tobit regression models for the natural logarithm (CAC score +1).

Results

The prevalence of detectable CAC (CAC score >0) was 11.7% (n = 2,604). After adjustment for age; sex; center; year of screening examination; education level; physical activity; smoking; alcohol intake; family history of cardiovascular disease; history of hypertension; history of hypercholesterolemia; and intake of total energy, fruits, vegetables, and red and processed meats, only the highest category of sugar-sweetened carbonated beverage consumption was associated with an increased CAC score compared with the lowest consumption category. The multivariable-adjusted CAC ratio comparing participants who consumed ≥5 sugar-sweetened carbonated beverages per week with nondrinkers was 1.70 (95% CI, 1.03-2.81). This association did not differ by clinical subgroup, including participants at low cardiovascular risk.

Conclusion

Our findings suggest that high levels of sugar-sweetened carbonated beverage consumption are associated with a higher prevalence and degree of CAC in asymptomatic adults without a history of cardiovascular disease, cancer, or diabetes.