Evaluation of the safety of primary metabolites of cyadox: Acute and sub-chronic toxicology studies and genotoxicity assessment
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- 作者：Qin Huanga ; Awais Ihsand ; Pu Guob ; Xun Luob ; Guyue Chengc ; Haihong Haoc ; Dongmei Chenc ; Farrukh Jamild ; Yanfei Taoc ; Xu Wangc ; wangxu@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zonghui Yuana ; b ; c ; yuan5802@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Quinoxaline ; Cyadox ; Genotoxicity ; Metabolites ; Acute toxicity ; Subchronic toxicity
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：123-136
- 全文大小：1598 K
文摘
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N–O reduced metabolites (Cy1, Cy2, Cy10) had no genotoxicity in three mutation tests.
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The maximum tolerated dose (MTD) of metabolites was above 6000 mg/kg b.w./day.
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The high-dose groups of Cy1 and Cy-M showed pathological changes in the liver.
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The NOAEL for subchronic study of the metabolites was 150 mg/kg diet for rats.