Regulation of viral gene expression by the herpes simplex virus 1 UL24 protein (HSV-1 UL24 inhibits accumulation of viral transcripts)
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- 作者：Carolina Sanabria-Solanoa ; Carmen Elena Gonzaleza ; Nicolas Richeriouxa ; Luc Bertranda ; 1 ; Slimane Dridia ; Anthony Griffithsc ; Yves Langelierb ; Angela Pearsona ; angela.pearson@iaf.inrs.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Herpes simplex virus 1 ; UL24 ; Viral gene regulation
- 刊名：Virology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：495
- 期：Complete
- 页码：148-160
- 全文大小：2922 K
文摘
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HSV-1 UL24 is sufficient to repress expression of several viral genes.
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Substitution of highly conserved residues in UL24 abrogates the repression function.
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A high GC content is not sufficient to render genes susceptible to repression by UL24.
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UL24 reduction of viral RNA levels does not appear to be due to altered RNA stability.