Improved bioavailability of targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiac microenvironment
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- 作者：Aramita Ray aramitaray@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author ; Santanu Rana rana.santanu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Durba Banerjee durba.research@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Arkadeep Mitra arkadeep.mitra@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ritwik Datta rdatta30@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shaon Naskar shaon.me@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sagartirtha Sarkar ; sagartirtha.sarkar@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ac-p53 ; acetylated p53 ; ANF ; atrial natriuretic factor ; AngII ; angiotensin II-induced cells ; AngIICur ; free Curcumin treated angiotensin II-induced cells ; AngIICurNP ; Curcumin/CMC-peptide nanoparticle treated angiotensin II-induced cells ; AngIIC646 ; C646 treated angiotensin II-induced cells ; AngIICurNP ; + ; MG ; Angiotensin II-induced cells co-treated with Curcumin nanoparticle and MG132 ; AngIIMG ; Angiotensin II-induced cells treated with MG132 ; Bax ; Bcl-2-associated X protein ; Bcl2 ; B-cel
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：290
- 期：Complete
- 页码：54-65
- 全文大小：1708 K
文摘
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Cardiomyocyte targeted Curcumin/CMC-peptide increases bioavailability of the drug.
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Curcumin nanoparticle regresses cardiac hypertrophy by reducing myocyte apoptosis.
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Targeted Curcumin shows higher efficacy over free Curcumin to regress hypertrophy.
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Curcumin modulates p300-HAT axis to facilitate p53 degradation.