Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23erl/erl mice
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- 作者：J. Hua ; b ; M. Xua ; J. Yuanb ; B. Lic ; S. Entenmanb ; H. Yub ; Q.Y. Zhenga ; b ; c ; qyz@case.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABR ; auditory-evoked brainstem response ; Cdh23 ; Cadherin23 ; DFNB ; autosomal recessive nonsyndromic deafness ; DPOAE ; distortion product oto-acoustic emission ; FDA ; Food and Drug Administration ; OHC ; outer hair cell ; PBS ; phosphate-buffered saline ; SEM ; scanning electron microscope ; s.e.m ; standard error of the mean ; SPL ; sound pressure level ; TNF ; transforming growth factor ; TUDCA ; tauroursodeoxycholic acid ; TUNEL ; terminal deoxynucleotidyl transferase dUTP nick end labeling ; UDCA ; ursodeoxycholi
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：316
- 期：Complete
- 页码：311-320
- 全文大小：1536 K
文摘
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Cdh23erl/erl mutant mouse is an established model of genetic hearing loss.
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Tauroursodeoxycholic acid (TUDCA) has been used in diseases related to apoptosis.
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We studied otoprotective effects and mechanisms of TUDCA in Cdh23erl/erl mice.
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TUDCA protects against hearing loss and hair cell death in Cdh23erl/erl mice.
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TUDCA partly inhibits the intrinsic apoptosis in Cdh23erl/erl mouse cochleae.