TrkB agonist, 7,8-dihydroxyflavone, reduces the clinical and pathological severity of a murine model of multiple sclerosis
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- 作者：Tapas K. Makara ; b ; c ; 1 ; tmakar@som.umaryland.edu" class="auth_mail" title="E-mail the corresponding author ; Vamshi K.C. Nimmagaddaa ; b ; 1 ; vnimmagadda@som.umaryland.edu" class="auth_mail" title="E-mail the corresponding author ; Ishwar S. Singhb ; d ; isingh@umaryland.edu" class="auth_mail" title="E-mail the corresponding author ; Kristal Lama ; knl2fv@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; Fahad Mubariza ; fahadm1@umbc.edu" class="auth_mail" title="E-mail the corresponding author ; Susan I.V. Judgea ; b ; c ; sjudge@som.umaryland.edu" class="auth_mail" title="E-mail the corresponding author ; David Trislera ; b ; c ; GTrisler@som.umaryland.edu" class="auth_mail" title="E-mail the corresponding author ; Christopher T. Bever Jra ; b ; c ; christopher.bever@va.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：EAE ; Experimental autoimmune encephalomyelitis ; MS ; Multiple Sclerosis ; DHF ; 7 ; 8-dihydroxyflavone ; TrkB ; Tropomyosin Related Kinase B receptor ; MOG ; Myelin oligodendrocyte glycoprotein ; CNS ; Central nervous system ; BBB ; Blood brain barrier
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：292
- 期：Complete
- 页码：9-20
- 全文大小：2985 K
文摘
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DHF reduces clinical severity in EAE.
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DHF suppresses inflammation and alters the cytokine profile in the CNS of EAE.
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DHF reduces demyelination and axonal damage, and promotes remyelination in the CNS of EAE.
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DHF reduces apoptosis in the CNS of EAE.
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DHF activates TrkB-AKT-STAT3 pathway in the CNS of EAE.