HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy

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• 作者：Marah El-Beeli^a ; ^{marah.eltahir@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Samira Hamad Al-Mahrooqi^a ; ^{samira.almahruqi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Randa Mahmoud Youssef^b ; ^{rahman.randa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Fahad Zadjali^c ; ^{fahad.alzadjali@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Abdullah Balkhair^d ; ^{balkhair2020@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mohammed Said Al-Balushi^a ; ^{albuloshi@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Elias Anthony Said^a ; ^{esaid@squ.edu.om" class="auth_mail" title="E-mail the corresponding author} ; Sidgi Syed Hasson^a ; ^{shyahasson@squ.edu.om" class="auth_mail" title="E-mail the corresponding author} ; Ali Abdullah Al-Jabri^a ; ^{aaljabri@squ.edu.om" class="auth_mail" title="E-mail the corresponding author}
• 关键词：HIV ; AIDS ; HLA ; cART ; Oman ; Immune response
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：77
• 期：6
• 页码：490-497
• 全文大小：829 K

文摘

Around 15–30% of AIDS patients fail to recover their CD4⁺ T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of <50 copies per ml were investigated. Viral load and CD4 T cells counts were performed following standard techniques. HLA genotyping was performed using PCR-SSP technique. The Statistical Package for Social Sciences (SPSS version 19) was used for data processing and analysis. A significantly higher proportion of poor immune responders were carrying HLA-A68 (4.8% compared to 25.0%, P = 0.025) and HLA-B15 (2.4% compared to 20.8%, P = 0.023). The etiological fraction (Efe%) among carriers of HLA-A68 was 57.89% (95% CI = 26.79, 75.79) and was 61.35% (95% CI = 35.33, 76.91) among carriers of HLA-B15.