Regional c-Fos expression induced by peripheral oxytocin administration is prevented by the vasopressin 1A receptor antagonist SR49059
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- 作者：Callum Hicksa ; chicks0333@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Linnet Ramosa ; lramos1984@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bruno Dampneyb ; b.dampney@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author ; Sarah J. Baracza ; Sarah.Baracz@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Iain S. McGregora ; Iain.McGregor@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Glenn E. Huntc ; glenn.hunt@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADP ; anterodorsal preoptic area ; ANOVA ; analysis of variance ; AVP ; arginine vasopressin ; BBB ; blood-brain barrier ; BNST ; bed nucleus of the stria terminalis ; CEA ; central amygdala ; CNS ; central nervous system ; CRH ; corticotrophin-releasing hormone ; DMSO ; dimethyl sulfoxide ; IP ; intraperitoneal ; LC ; locus coeruleus ; LPB ; lateral parabrachial nucleus ; LSV ; lateral septal nucleus ; MPA ; medial preoptic area ; NTS ; nucleus of the solitary tract ; OTR ; oxytocin receptor ; PB ; phosphate buffer ; PBS ; phosp
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：208-218
- 全文大小：2686 K
文摘
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Peripheral oxytocin administration reduces locomotor activity in rats.
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The V1A receptor antagonist SR49059 blocks oxytocin-induced hypo-locomotion.
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Oxytocin increases Fos expression in neurons, including oxytocin producing neurons.
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SR49059 reduced oxytocin-driven Fos activation in the hypothalamus and brain stem.
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Many of the functional and neural effects of oxytocin may be V1AR mediated.