To determine whether the peak heart rate reached during a six-minute walk test (HR6peak) can be used to predict the heart rate determined at the gas exchange threshold (HRGET) during a maximal cardiopulmonary exercise test (CPET) in patients with cystic fibrosis (CF). To assess the test-retest reliability of HR6peak.
Case-control and reliability study.
CF unit.
Adults with CF (n=23) and age-matched sedentary subjects (control group, n=17).
Not applicable.
Six-minute walk test, HR6peak, CPET, and HRGET.
HRGET and HR6peak were not significantly different and were highly correlated in both groups (CF, r=.91, P<.01; controls, r=.81, P<.01). The mean differences (HR6peak–HRGET) for patients with CF and control subjects were, respectively, −0.9 beats·min−1 (bpm) and –0.1bpm, with neither significantly different from 0. The limits of agreements were ±11bpm and ±18bpm, respectively. HR6peak demonstrated excellent relative reliability (intraclass correlation coefficient=.93) and was associated with low variability (standard error of measurement=4.9bpm) in patients with CF.
HR6peak is valid and demonstrates satisfactory test-retest reliability in patients with CF. These results might suggest the use of HR6peak as a simple alternative method to individualize exercise prescriptions in this population. Further studies are needed in a larger cohort of patients to confirm these preliminary findings.