Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A
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- 作者：Glenn Gauderata ; b ; c ; glenn.gauderat@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nicole Picard-Hagena ; b ; n.hagen-picard@envt.fr" class="auth_mail" title="E-mail the corresponding author ; Pierre-Louis Toutaina ; b ; pltoutain@wanadoo.fr" class="auth_mail" title="E-mail the corresponding author ; Tanguy Corbela ; b ; tanguycorbel30@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Catherine Viguié ; a ; b ; c.viguie@envt.fr" class="auth_mail" title="E-mail the corresponding author ; Sylvie Puela ; b ; s.puel@envt.fr" class="auth_mail" title="E-mail the corresponding author ; Marlè ; ne Z. Lacroixa ; b ; m.lacroix@envt.fr" class="auth_mail" title="E-mail the corresponding author ; Pierre Mindeguiaa ; b ; p.mindeguia_12@envt.fr" class="auth_mail" title="E-mail the corresponding author ; Alain Bousquet-Meloua ; b ; a.bousquet-melou@envt.fr" class="auth_mail" title="E-mail the corresponding author ; Vé ; ronique Gayrarda ; b ; Gayrardv.gayrard@envt.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bisphenol A ; Bisphenol A glucuronide ; Hydrolysis ; Fetus ; Toxicokinetic
- 刊名：Environment International
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：52-59
- 全文大小：751 K
文摘
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Fetal sheep was used to evaluate BPA and BPAG toxicokinetic parameters.
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The fetal to maternal transfer and the extent of BPA conjugation were 70 and 30%.
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Fetal BPAG elimination involved hydrolysis.
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The hydrolysis of BPAG resulted in a highly increased persistence of fetal BPA.