A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma

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作者：Christine H. Chung^a ; ^c ; ^{christine.chung@moffitt.org" class="auth_mail" title="E-mail the corresponding author} ; Michelle A. Rudek^a ; ^{mrudek2@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Hyunseok Kang^a ; ^{hkang30@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Shanthi Marur^a ; ^{smarur1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Pritish John^a ; ^{pjohn5@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Nancy Tsottles^a ; ^{tsottna@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Sarah Bonerigo^a ; ^{sboneri1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Andy Veasey^d ; ^{Andy.Veasey@cgix.com" class="auth_mail" title="E-mail the corresponding author} ; Ana Kiess^a ; ^{akiess1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Harry Quon^a ; ^{hquon2@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Anthony Cmelak^b ; ^{anthony.cmelak@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author} ; Barbara A. Murphy^b ; ^{barbara.murphy@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author} ; Jill Gilbert^b ; ^{jill.gilbert@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Afatinib ; Carboplatin ; Paclitaxel ; Head and neck squamous cell carcinoma ; Efficacy ; Toxicity ; ABCB1 ; Phase I trial
刊名：Oral Oncology
出版年：2016
出版时间：February 2016
年：2016
卷：53
期：Complete
页码：54-59
全文大小：455 K

文摘

class="label">•: Maximum tolerated dose of afatinib with carboplatin/paclitaxel is 20 mg daily.
class="label">•: Afatinib at doses >20 mg with carboplatin/paclitaxel should be used with caution.
class="label">•: Afatinib needs further evaluation in management of newly diagnosed HNSCC.

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