Anterior insula coordinates hierarchical processing of tactile mismatch responses
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A body-related network of thalamic, somatosensory, insular, cingulate, and prefrontal areas responded to tactile oddballs.

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Dynamic Causal Modelling revealed oddball stimuli modulated an ascending rostral-to-caudal hierarchy between these areas.

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Within this feed-forward flow, only anterior insula showed reciprocal increases in connectivity with somatosensory cortex.

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Subjective deviance detection ratings predicted the strength of feedback from prefrontal cortex to anterior insula

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These results provide preliminary evidence for the newly emerging theory of embodied predictive coding.

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