Association of vaccine handling conditions with effectiveness of live attenuated influenza vaccine against H1N1pdm09 viruses in the United States
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- 作者：Herve Caspard ; caspardh@medimmune.com" class="auth_mail" title="E-mail the corresponding author ; Kathleen L. Coelingh1 ; kcoelingh@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Raburn M. Mallory malloryr@medimmune.com" class="auth_mail" title="E-mail the corresponding author ; Christopher S. Ambrose ambrosec@medimmune.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CDC ; US Centers for Disease Control and Prevention ; E47 ; glutamic residue at position 47 ; IIV ; inactivated influenza vaccine ; LAIV ; live attenuated influenza vaccine ; SPSN ; Sentinel Provider Surveillance Network ; TNCC ; test-negative case control ; US ; United States ; VE ; vaccine effectiveness
- 刊名：Vaccine
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：34
- 期：42
- 页码：5066-5072
- 全文大小：850 K
文摘
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In 2013–2014, LAIV was effective against influenza B but not A/H1N1pdm09 in the US.
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Lot shipping date and outdoor temperature were associated with VE against A/H1N1.
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New analyses showed no significant LAIV VE against H1N1pdm09 in 2010–2011 in the US.
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From 2010 to 2014, moderate to high VE for LAIV was observed against A/H3N2 and B.
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A more heat-stable A/H1N1pdm09 LAIV strain was manufactured for 2015–2016.