Potent Antibody Protection against an Emerging Alphavirus Threat

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• 作者：Margaret Kielian¹ ; ^{margaret.kielian@einstein.yu.edu" class="auth_mail" title="E-mail the corresponding author} ; Erica Ollmann Saphire² ; ³ ; ^{erica@scripps.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell
• 出版年：2015
• 出版时间：19 November 2015
• 年：2015
• 卷：163
• 期：5
• 页码：1053-1054
• 全文大小：272 K

文摘

Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.