Cytotoxicity and apoptotic activity of novel organobismuth(V) and organoantimony(V) complexes in different cancer cell lines
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- 作者：Arshad Islama ; b ; arshad.cgl@gmail.com" class="auth_mail" title="E-mail the corresponding author ; arshad@ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Bernardo Lages Rodriguesb ; bernardo@mail.qui.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Ivana Marques Marzanob ; ivanadq@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Elene C. Perreira-Maiab ; elene@qui.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Dalton Dittzc ; daltondittz@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Miriam Teresa Paz Lopesc ; mtpl@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Muhammad Ishfaqd ; e ; M.ishfaq@southampton.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Fré ; dé ; ric Fré ; zarda ; frezard@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Cynthia Demichelib ; cynthia.demicheli@pq.cnpq.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Organobismuth(V) dicarboxylates ; Organoantimony(V) dicarboxylates ; Crystal structure ; Cytotoxic activity ; Apoptosis ; Flow cytometry
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：254-267
- 全文大小：2227 K
文摘
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Synthesis of Bi(V) and Sb(V) complexes with carboxylic acid derivatives.
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Sb(V) complexes class="boldFont">2 and class="boldFont">4 crystals were characterized by single X-ray diffraction.
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All complexes were evaluated for their cytotoxic activity.
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Bi(V) complexes were more selective for cancerous cell lines than Sb(V) ones.
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Bi(V) complex class="boldFont">1 was investigated to induce apoptosis in B16F10 cells.