Surface plasmon resonance biosensor for enzyme-free amplified microRNA detection based on gold nanoparticles and DNA supersandwich
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- 作者：Qing WangAuthor Vitae ; Rongjuan LiuAuthor Vitae ; Xiaohai Yang ; yangxiaohai@hnu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Kemin Wang ; kmwang@hnu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Jinqing ZhuAuthor Vitae ; Leiliang HeAuthor Vitae ; Qing LiAuthor Vitae
- 关键词：Surface plasmon resonance ; MicroRNA ; Gold nanoparticles ; Supersandwich
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：223
- 期：Complete
- 页码：613-620
- 全文大小：1095 K
文摘
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A novel enzyme-free amplified SPR biosensor for microRNA detection was introduced.
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This assay showed excellent sensitivity due to the dual signal amplification.
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This approach showed good selectivity, resulting in its application in serum sample.