In vivo protein targets for increased quinoprotein adduct formation in aged substantia nigra
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- 作者：Guohua Yua ; xiaoqsh2003@163.com" class="auth_mail" title="E-mail the corresponding author ; Huiyan Liua ; Wei Zhoua ; Xuewei Zhua ; Chao Yua ; Na Wanga ; Yi Zhanga ; Ji Maa ; Yulan Zhaoa ; Yuanyuan Xua ; Lujian Liaoc ; Hongfang Jid ; Chonggang Yuana ; Jiyan Maa ; b ; jiyan.ma@vai.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：PD ; Parkinson's disease ; DA ; dopamine ; DAQ ; dopamine quinone ; SN ; substantia nigra ; NBT ; nitroblue tetrazolium ; GSH ; reduced glutathione ; LDH ; lactate dehydrogenase ; MDH ; malate dehydrogenase
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：271
- 期：Complete
- 页码：13-24
- 全文大小：1569 K
文摘
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Quinoprotein adducts in the substantia nigra of 2- and 15-month rats were compared.
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In vivo proteins with increased quinone modification in aged substantia nigra were identified.
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Four of the five identified proteins were key enzymes involved in energy metabolism.
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Two of identified enzymes were readily modified by dopamine quinone in vitro.
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Dopamine quinone modification significantly reduced enzyme activity.