The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia
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- 作者：Eva Koseka ; b ; Eva.Kosek@ki.se" class="auth_mail" title="E-mail the corresponding author ; Sofia Martinsena ; Sofia.Martinsen@ki.se" class="auth_mail" title="E-mail the corresponding author ; Bjö ; rn Gerdlec ; Bjorn.Gerdle@liu.se" class="auth_mail" title="E-mail the corresponding author ; Kaisa Mannerkorpid ; e ; Kaisa.Mannerkorpi@neuro.gu.se" class="auth_mail" title="E-mail the corresponding author ; Monika Lö ; fgrenf ; Monika.Lofgren@ki.se" class="auth_mail" title="E-mail the corresponding author ; Indre Bileviciute-Ljungarf ; indre@ljungar.se" class="auth_mail" title="E-mail the corresponding author ; Peter Franssona ; Peter.Fransson@ki.se" class="auth_mail" title="E-mail the corresponding author ; Martin Schallingg ; Martin.Schalling@ki.se" class="auth_mail" title="E-mail the corresponding author ; Martin Ingvara ; Martin.Ingvar@ki.se" class="auth_mail" title="E-mail the corresponding author ; Malin Ernbergh ; Malin.Ernberg@ki.se" class="auth_mail" title="E-mail the corresponding author ; Karin B. Jensena ; Karin.Jensen@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fibromyalgia ; Translocator protein ; Serotonin ; Genetic polymorfisms ; Functional magnetic resonance imaging ; Serotonin transporter ; SCL6A4 ; rs6971 ; 5-HTTLPR ; Gene-to-gene interactions
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：218-227
- 全文大小：646 K
文摘
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Glia activation is associated with up-regulation of TSPO in chronic pain.
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Pain and fibromyalgia (FM) symptoms were associated with a TSPO polymorphism.
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A TSPO/serotonin transporter gene-to-gene interaction influenced FM pain.
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TSPO affected the emotional-motivational components of pain perception in FM.
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TSPO may be a new target for drug development in chronic widespread pain.