Endobronchial ultrasound-guided transbronchial needle aspiration is useful as an initial procedure for the diagnosis of lymphoma

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• 作者：Potjanee Korrungruang^a ; ^b ; ^{potjanee_krr@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Masahide Oki^a ; ^{masahideo@aol.com" class="auth_mail" title="E-mail the corresponding author} ; Hideo Saka^a ; ^{saka@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshihito Kogure^a ; ^{yo-kogure@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Rie Tsuboi^a ; ^{riems215@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Saori Oka^a ; ^{saorioka.a@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Masashi Nakahata^a ; ^{nakahtms1231@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kazumi Hori^a ; ^{flavored_coffee10@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Yasushi Murakami^a ; ^{konyasu222@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yuko Ise^a ; ^{yuko0525ise@hotmail.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Shimaa Nour Moursi Ahmed^a ; ^{drshaimaa76@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Chiyoe Kitagawa^a ; ^{kitagawc@nnh.hosp.go.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：EBUS-TBNA ; endobronchial ultrasound-guided transbronchial needle aspiration ; EUS-FNA ; endoscopic ultrasound-guided fine-needle aspiration ; ROSE ; rapid on-site cytological examination
• 刊名：Respiratory Investigation
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：54
• 期：1
• 页码：29-34
• 全文大小：374 K

文摘

The usefulness of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for evaluating hilar, mediastinal and central parenchymal lesions has been well established. However, its utility for diagnosing lymphoma is controversial. The aim of this study was to evaluate the diagnostic utility of EBUS-TBNA for the definitive diagnosis of de novo lymphoma with subtype classification.

Methods

Patients with lymphoma who underwent EBUS-TBNA for diagnostic purposes at a single institution between March 2004 and May 2013 were retrospectively reviewed.

Results

Of the 971 patients who underwent EBUS-TBNA during the study period, 19 patients, who did not have a previous history of lymphoma, had a final diagnosis of lymphoma. EBUS-TBNA provided a diagnosis accompanied with subtype classification in 6 patients (32%), a suspicious but not definitive classification in 10 patients (53%), and a negative classification in 3 patients (16%). Immunohistochemical staining for definitive diagnosis was performed in 15 of 16 patients (94%), with suspicious results from routine hematoxylin and eosin staining. No procedure-related complications occurred.

Conclusions

EBUS-TBNA is a useful initial diagnostic procedure, aiding decisions for the management of patients with suspected lymphoma, even though the sensitivity of EBUS-TBNA for diagnosing lymphoma with subtype classification was lower than previously reported.