Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains
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- 作者：Fahu He1 ; 5 ; Hans-Peter Wollscheid2 ; 5 ; 6 ; Urszula Nowicka1 ; Matteo Biancospino2 ; Eleonora Valentini2 ; Aaron Ehlinger3 ; 7 ; Filippo Acconcia2 ; 8 ; Elisa Magistrati2 ; Simona Polo2 ; 4 ; simona.polo@ifom.eu" class="auth_mail" title="E-mail the corresponding author ; Kylie J. Walters1 ; kylie.walters@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：22 March 2016
- 年：2016
- 卷：14
- 期：11
- 页码：2683-2694
- 全文大小：4158 K
文摘
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Myosin VI contains a compact structural motif that binds ubiquitin chains
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MyUb nestles between ubiquitins of K63-linked chains
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Optineurin interaction requires an expanded MyUb and capacity to bind ubiquitin
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An isoform-specific helix restricts MyUb binding to ubiquitin chains