Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies
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- 作者：Shannon L. Glisana ; Kimberly A. Grovea ; Neela H. Yennawarb ; Joshua D. Lamberta ; c ; jdl134@psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Theaflavin (PubChem CID ; 114777) ; Theaflavin-3-gallate (PubChem CID ; 169167) ; Theaflavin-3&prime ; -gallate (PubChem CID ; 71307578) ; Theaflavin-3 ; 3&prime ; -gallate (PubChem CID ; 3589471)
- 刊名：Food Chemistry
- 出版年：2017
- 出版时间：1 February 2017
- 年：2017
- 卷：216
- 期：Complete
- 页码：296-300
- 全文大小：1022 K
文摘
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Theaflavins inhibit pancreatic lipase (PL) at physiological concentrations.
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Theaflavin-3,3′-digallate (TFdiG) is the most potent inhibitor.
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TFdiG inhibits PL in a non-competitive manner with regard to substrate.
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An in silico model predicts that TFdiG binds adjacent to the PL active site.
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The model predicts that TFdiG perturbs His264, the key catalytic amino acid.