PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells
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- 作者：Noemi Arrighettia ; Noemi.Arrighetti@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Giacomo Cossaa ; Gia.Cossa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Loris De Ceccob ; Loris.Dececco@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Simone Stucchia ; Simone.Stucchi@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Nives Careninia ; Nives.Carenini@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Elisabetta Cornaa ; Elisabetta.Corna@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Paolo Gandellinia ; Paolo.Gandellini@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Nadia Zaffaronia ; Nadia.Zaffaroni@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Paola Peregoa ; paola.perego@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Laura Gattia ; Laura.Gatti@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：API5 ; apoptosis inhibitor 5 ; ARF1 ; ADP ribosylation factor 3 ; BCA ; bicinchoninic acid ; BBC3/PUMA ; BCL2 binding component 3 ; BIRC5 ; baculoviral IAP (inhibitor of apoptosis) repeat containing 5 ; CDC25A ; cell division cycle 25A ; CDK4 ; cyclin-dependent kinase 4 ; CDK6 ; cyclin-dependent kinase 6 ; Chk1 ; checkpoint kinase 1 ; FACS ; Fluorescence-activated cell sorting ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GO ; Gene Ontology ; IGF2 ; insulin-like growth factor 2 ; miRNA ; microRNA ; MRP2 ; ABC transpo
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：310
- 期：Complete
- 页码：9-19
- 全文大小：846 K
文摘
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miR-483-3p is up-regulated in ovarian carcinoma cells resistant to platinum drugs.
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Ectopic expression of miR-483-3p in IGROV-1 confers mild levels of Pt-resistance.
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Overexpression of miR-483-3p down-regulates PRKCA levels in ovarian carcinoma cells.
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miR 483–3p directly targets PRKCA 3′UTR in IGROV-1 cells.
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The contribution of miR-483-3p to Pt-resistance is related to cell proliferation.