Study of exhaled breath condensate sample preparation for metabolomics analysis by LC-MS/MS in high resolution mode
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- 作者：M.A. Ferná ; ndez-Peralboa ; b ; M. Calderó ; n Santiagoa ; b ; F. Priego-Capotea ; b ; q72prcaf@uco.es" class="auth_mail" title="E-mail the corresponding author ; M.D. Luque de Castroa ; b ; qa1lucam@uco.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：EBC ; Exhaled breath condensate ; MSC ; Micro spin cartridges ; HI ; Hydrophilic interaction ; TIC ; Total ion chromatogram ; PP ; Protein precipitation ; VOCs ; Volatile organic compounds
- 刊名：Talanta
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：144
- 期：Complete
- 页码：1360-1369
- 全文大小：1432 K
文摘
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Analysis of EBC components requires a sample preparation–preconcentration step.
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Lyophilization is the best preconcentration option for EBC.
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The EBC matrix does not interfere in analyses by LC–QTOF, avoiding separation steps.
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Identified compounds in EBC were discussed from a biochemical point of view.