Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American—Diabetes Heart Study
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- 作者：Nicholette D. Palmera ; b ; c ; d ; nallred@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Jasmin Diversd ; e ; jdivers@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Lingyi Lud ; e ; llu@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Thomas C. Registerf ; register@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; J. Jeffrey Carri ; j.jeffrey.carr@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Pamela J. Hicksa ; panderso@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; S. Carrie Smitha ; suscsmit@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Jianzhao Xuc ; jixu@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Suzanne E. Juddj ; sejudd@uab.edu" class="auth_mail" title="E-mail the corresponding author ; Marguerite R. Irvink ; irvinr@uab.edu" class="auth_mail" title="E-mail the corresponding author ; Orlando M. Gutierrezk ; l ; ogutierr@uab.edu" class="auth_mail" title="E-mail the corresponding author ; Donald W. Bowdena ; b ; c ; dbowden@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Lynne E. Wagenknechtg ; lwgnkcht@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Carl D. Langefeldd ; e ; clangefe@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Barry I. Freedmanb ; c ; d ; h ; bfreedma@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Epidemiology ; Human association studies ; Intact parathyroid hormone ; Vitamin D ; Bone mineral density
- 刊名：Bone
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：71-77
- 全文大小：828 K
文摘
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Admixture mapping can be used to identify genomic regions contributing to ethnic differences in vitamin D, iPTH, and BMD.
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Novel loci linked to 1,25-dihydroxyvitamin D were identified on 13q21.2 (LOD = 3.20) and 12q13.2 (LOD = 3.10).
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iPTH was significantly linked to 9q31.3 (rs7854368, LOD = 3.14) proximal to a regulatory protein of sodium-phosphate cotransport (AKAP).
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Fine-mapping of admixture peaks has focused efforts to identify loci with ethnic differences in vitamin D-related traits.