HCV1b genome evolution under selective pressure of the cyclophilin inhibitor alisporivir during the DEB-025-HCV-203 phase II clinical trial
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- 作者：Lize Cuypersa ; 1 ; lize.cuypers@kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Joke Snoecka ; 1 ; 2 ; joke.snoeck@nds.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Lien Kerremansa ; 3 ; lienkerremans@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Pieter Libinb ; a ; pieter.libin@vub.ac.be" class="auth_mail" title="E-mail the corresponding author ; Raf Crabbé ; c ; rcrabbe@debiopharm.com" class="auth_mail" title="E-mail the corresponding author ; Sonia Van Doorena ; 4 ; sonia.vandooren@uzbrussel.be" class="auth_mail" title="E-mail the corresponding author ; Gré ; goire Vuagniauxc ; gregoire.vuagniaux@debiopharm.com" class="auth_mail" title="E-mail the corresponding author ; Anne-Mieke Vandammea ; d ; annemie.vandamme@uzleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：BL ; baseline ; BLQ ; below limit of quantification ; BN ; Bayesian network ; (c)DNA ; (copy) deoxyribonucleic acid ; CsA ; cyclosporine A ; DAA ; direct-acting antiviral ; dN ; non-synonymous nucleotide change ; dS ; synonymous nucleotide change ; EC50 ; half maximal effective concentration ; EDTA ; ethylenediaminetetraacetic acid ; GT ; genotype ; GTR ; generalized time reversible ; HCV ; hepatitis C virus ; HIV ; human immunodeficiency virus ; HTA ; host-targeting antiviral ; HVR1 ; hypervariable region-1 ; ID ; identificati
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：169-181
- 全文大小：1011 K
文摘
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A large variation of amino acid changes over time was observed for all subjects.
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NS5A drug resistant variant D320E, detected in vitro, was found in two subjects.
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A low number of positions under positive selective pressure was detected.
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Power to assess links of alisporivir/interferon with amino acid changes was limited.