MicroRNA-21 as a novel biomarker in diagnosis and response to therapy in asthmatic children
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- 作者：Rabab M. Elbehidya ; Doaa M. Youssefa ; Amal S. El-Shalb ; amalelshal@gmail.com" class="auth_mail" title="E-mail the corresponding author ; amalelshal@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Sally M. Shalabyb ; Hanan S. Sherbinya ; Laila M. Sheriefa ; Nagwa E Akeela
- 关键词：Asthma ; miRNA ; miRNA -21 ; Steroid therapy ; Real-time polymerase chain reaction
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：107-114
- 全文大小：798 K
文摘
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expression levels of miRNA-21 were higher in the asthmatic children.
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IL12 p35 levels were significantly decreased in asthmatic patients.
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serum miRNA-21 expression was correlated with serum IL12 p35 levels and FEV1.
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miRNA-21 has differentiates ICS sensitive from ICS resistant.