Antimicrobial Efficacy of 3.8% Silver Diamine Fluoride and Its Effect on Root Dentin

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• 作者：Noriko Hiraishi ; DDS ; PhD^&lowast ; ; ^&dagger ; ; ^{hiraishinoriko@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Cynthia K.Y. Yiu ; BDS ; PhD^&dagger ; ; Nigel M. King ; BDS ; MS ; PhD^&dagger ; ; Junji Tagami ; DDS ; PhD^&lowast ; ; ^&Dagger ; ; Franklin R. Tay ; BDSc (Hons) ; PhD^§ ;
• 关键词：Antimicrobial ; Enterococcus faecalis ; irrigant ; root canal medicament ; silver diamine fluoride
• 刊名：Journal of Endodontics
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：36
• 期：6
• 页码：1026-1029
• 全文大小：433 K

文摘

This study investigated the use of 3.8% silver diamine fluoride (Ag[NH₃]₂F) as an antibacterial agent against Enterococcus faecalis biofilms and its ability to penetrate dentinal tubules by the formation of silver salts.

Methods

Biofims were generated on membrane filter discs and subjected to 15-minute and 60-minute exposure times with 3.8% Ag(NH₃)₂F, saturated Ca(OH)₂, 5.25% NaOCl (negative control), and 0.9% NaCl (positive control). Cleaned and shaped radicular dentin were applied with Ag(NH₃)₂F for 24, 48, and 72 hours. The presence of silver salts on the dentin surface was examined using low-pressure scanning electron microscopy.

Results

Both NaOCl and Ag(NH₃)₂F were effective against E. faecalis biofilms, with no significant difference in reduction of microorganisms for both exposure times. Silver deposits were present on 66.5% of the radicular dentin surfaces after 72-hour application of Ag(NH₃)₂F as simulated interappointment dressings. Penetration of the silver deposits was observed at most 40 μm into dentinal tubules after smear layer removal.

Conclusion

Ag(NH₃)₂F has potential to be used as an antimicrobial root canal irrigant or interappointment dressing, especially in locations in which potential browning/blackening of dentin by metallic silver is not a major concern.