Positive regulation of HIF-1A expression by EBV oncoprotein LMP1 in nasopharyngeal carcinoma cells
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- 作者：Wei-Wen Sunga ; Yi-Chih Chub ; Peir-Rong Chenc ; Ming-Hui Liaoa ; mhliao@mail.npust.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Jeng-Woei Leed ; e ; jwlee@mail.tcu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：EBV ; LMP-1 ; HIF-1α ; Nasopharyngeal carcinoma
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：382
- 期：1
- 页码：21-31
- 全文大小：2391 K
文摘
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LMP1 up-regulates HIF-1A transcription and post-transcription in NPC cells.
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Down-regulation of RNA-destabilizing proteins contributes to stabilize HIF-1α mRNA.
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LMP1 facilitates HIF-1A promoter activity and positive auto-regulation of HIF-1α.