Organ- and species-specific biological activity of rosmarinic acid
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- 作者：R. Iswandanaa ; b ; raditya.iswandana@rug.nl" class="auth_mail" title="E-mail the corresponding author ; B.T. Phama ; c ; b.t.pham@rug.nl" class="auth_mail" title="E-mail the corresponding author ; W.T. van Haaftena ; w.t.van.haaften@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; T. Luangmonkonga ; d ; t.luangmonkong@rug.nl" class="auth_mail" title="E-mail the corresponding author ; D. Oosterhuisa ; d.oosterhuis@rug.nl" class="auth_mail" title="E-mail the corresponding author ; H.A.M. Mutsaersa ; 1 ; h.a.m.mutsaers@rug.nl" class="auth_mail" title="E-mail the corresponding author ; P. Olingaa ; 1 ; p.olinga@rug.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antifibrotic ; Anti-inflammatory ; Precision-cut intestinal slices ; Precision-cut liver slices ; Rosmarinic acid ; Toxicity
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：261-268
- 全文大小：1123 K
文摘
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We observed clear organ- and species-specific effects of Rosmarinic acid.
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Rosmarinic acid appears to elicit anti-inflammatory and antifibrotic effects in murine precision-cut intestinal slices.
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Rosmarinic acid beneficial effects were not observed in human and rat precision-cut intestinal slices.
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Rosmarinic acid has potential as a therapeutic agent for the treatment of liver fibrosis.