Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway
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- 作者：Yishu Yanga ; Lili Wangb ; Yan Wuc ; Dongmei Sub ; Ning Wangb ; Jiedong Wangb ; Cuige Shib ; yushuiyushui@sina.com" class="auth_mail" title="E-mail the corresponding author ; Liping Lvd ; lvlp2007@sina.com" class="auth_mail" title="E-mail the corresponding author ; Shucheng Zhangb ; nrifp@263.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vascular dementia ; Tanshinol ; Inflammation ; MST1 ; FOXO3
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：304-314
- 全文大小：1423 K
文摘
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TSL could improve the work memory.
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TSL inhibited the over-activation of pro-inflammatory mediators.
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TSL protected against LPS-induced cell injury.
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TSL could attenuated MST1-FOXO3 nuclear translocation.