Effects of late exercise on cardiac remodeling and myocardial calcium handling proteins in rats with moderate and large size myocardial infarction

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• 作者：Daniele M. Guizoni^a ; Silvio A. Oliveira-Junior^b ; Sefora L.R. Noor^a ; Luana U. Pagan^a ; Paula F. Martinez^a ; ^b ; Aline R.R. Lima^a ; Mariana J. Gomes^a ; Ricardo L. Damatto^a ; Marcelo D.M. Cezar^a ; Camila Bonomo^a ; Leonardo A.M. Zornoff^a ; Katashi Okoshi^a ; Marina P. Okoshi^a ; ^{mpoliti@fmb.unesp.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Myocardial infarction ; Physical exercise ; Cardiac function ; Echocardiogram ; Calsequestrin ; Remodeling
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：221
• 期：Complete
• 页码：406-412
• 全文大小：649 K

文摘

Physical exercise attenuates myocardial infarction (MI)-induced cardiac remodeling. However, it is unsettled whether late exercise modulates post-infarction cardiac remodeling differentially according to infarct size. We investigated the effects of exercise started at late stage heart failure on cardiac remodeling in rats with moderate and large sized MI.

Methods

Three months after MI, rats were assigned into sedentary and exercise groups. Exercise rats underwent treadmill for three months. After assessing infarct size by histological analysis, rats were subdivided into four groups: moderate MI sedentary (Mod MI-Sed; n = 7), Mod MI exercised (Mod MI-Ex; n = 7), Large MI-Sed (n = 11), and Large MI-Ex (n = 10).

Results

Before exercise, MI-induced cardiac changes were demonstrated by comparing results to a Sham group; alterations were more intense in rats with large than moderate MI size. Systolic function, evaluated by echocardiogram using the variation in LV fractional area change between after and before exercise, was improved in exercise than sedentary groups. Calsequestrin expression increased in exercised compared to sedentary groups. L-type calcium channel was higher in Mod MI-Ex than Mod MI-Sed. SERCA2a, phospholamban, and Na⁺/Ca^2 + exchanger expression did not differ between groups.

Conclusion

Late exercise improves systolic function and modulates intracellular calcium signaling proteins in rats with moderate and large MI.