Rb, but not p107 or p130, negatively regulates the kinase activity of mTORC2
Hyper-phosphorylated Rb interacts with Sin1 to block the access of Akt to mTORC2
Inhibiting Rb phosphorylation leads to elevated Akt-pS473 to confer drug resistance
A CDK4/6 inhibitor synergizes with an Akt inhibitor in treating Rb-positive cancer cells