LGX818 exhibits anti-proliferative activity in BRAFV600E melanoma cells.
GSK3β does not contribute to LGX818-triggered turnover of CyclinD1.
LGX818 induces senescence rather than apoptosis in BRAFV600E melanoma cells.
LGX818 triggers autophagy by inhibiting the mTOR pathway in BRAFV600E melanoma cells.
Autophagy plays a role in LGX818-induced senescence.