Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting

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• 作者：Yiannis Sarigiannis^a ; ¹ ; ² ; Αrgiris Kolokithas-Ntoukas^a ; ² ; Nicolas Beziere^b ; Radek Zbořil^c ; Evangelia Papadimitriou^d ; Konstantinos Avgoustakis^d ; Margarita Lamprou^d ; Zdenka Medrikova^c ; Elias Rousalis^a ; Vasilis Ntziachristos^b ; ^{v.ntziachristos@tum.de" class="auth_mail" title="E-mail the corresponding author} ; Aristides Bakandritsos^a ; ^c ; ^{aristeidis.bakandritsos@upol.cz" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Hybrid colloids ; Nanocrystal clusters ; Magnetic targeting ; Optoacoustic imaging ; Hyperthermia ; Theranostics
• 刊名：Biomaterials
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：91
• 期：Complete
• 页码：128-139
• 全文大小：2341 K

文摘

Colloidal clusters of magnetic iron oxide nanocrystals (MIONs), particularly in the condensed pattern (co-CNCs), have emerged as new superstructures to improve further the performance of MIONs in applications pertaining to magnetic manipulation (drug delivery) and magnetic resonance imaging (MRI). Exploitation of the advantages they represent and their establishment in the area of nanomedicine demands a particular set of assets. The present work describes the development and evaluation of MION-based co-CNCs featuring for the first time such assets: High magnetization, as well as magnetic content and moment, high relaxivities (r₂ = 400 and class="mathmlsrc">title="View the MathML source" class="mathImg" data-mathURL="/science?_ob=MathURL&_method=retrieve&_eid=1-s2.0-S0142961216300369&_mathId=si1.gif&_user=111111111&_pii=S0142961216300369&_rdoc=1&_issn=01429612&md5=81e11c2f6242ea09d8045b8dbc3f6af5">class="imgLazyJSB inlineImage" height="17" width="144" alt="View the MathML source" title="View the MathML source" src="/sd/grey_pxl.gif" data-inlimgeid="1-s2.0-S0142961216300369-si1.gif">class="mathContainer hidden">class="mathCode">${r_2}^{\text{*}}{=905\text{s}}^{-1}{{\text{mM}}_{\text{Fe}}}^{-1}$) and intrinsic loss power (2.3 nH m² kg_Fe⁻¹) are combined with unprecedented colloidal stability and structural integrity, stealth and drug-loading properties. The reported nanoconstructs are endowed with additional important features such as cost-effective synthesis and storage, prolonged self-life and biocompatibility. It is finally showcased with in vivo multispectral optoacoustic tomography how these properties culminate in a system suitable for targeting breast cancer and for forceful in vivo manipulation with low magnetic field gradients.