Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury
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- 作者：Wenting Zhanga ; c ; d ; 1 ; Hui Zhanga ; b ; 1 ; Hongfeng Mua ; Wen Zhuc ; d ; Xiaoyan Jianga ; c ; d ; Xiaoming Hua ; c ; d ; Yejie Shic ; d ; Rehana K. Leake ; Qiang Donga ; b ; Jun Chena ; c ; d ; f ; chenj2@upmc.edu" class="auth_mail" title="E-mail the corresponding author ; Yanqin Gaoa ; c ; d ; yqgao@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BBB ; blood‐brain barrier ; Col-IV ; collagen IV ; DHA ; docosahexaenoic acid ; EPA ; eicosapentaenoic acid ; EB ; evans blue ; FcRn ; neonatal Fc receptor ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; H/I ; hypoxic/ischemic ; LRP1 ; low-density lipoprotein receptor-related protein 1 ; MMP ; matrix metalloproteinase ; PUFA ; polyunsaturated fatty acids ; SDS-PAGE ; sodium dodecyl sulfate polyacrylamide gel electrophoresis ; TJ ; tight junction ; vWF ; von Willebrand factor
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：37-46
- 全文大小：2723 K
文摘
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Blood brain barrier was damaged after neonatal hypoxic–ischemic (H/I) brain injury.
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n‐3 PUFA preserved the integrity of blood brain barrier following H/I.
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n‐3 PUFA alleviated degeneration of tight junction after neonatal H/I insult.
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n‐3 PUFA suppressed H/I induced activation of MMP-9 and MMP-2 both in brain and in blood.