Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia

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• 作者：Hamzah A. Mohd^a ; ^{dr.hmohd@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ziad A. Memish^a ; ^b ; ^{zmemish@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Sarah H. Alfaraj^c ; ^{alfarajsa@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Donna McClish^d ; ^{donna.mcclish@vcuhealth.org" class="auth_mail" title="E-mail the corresponding author} ; Talal Altuwaijri^e ; ^{altuwaijrit@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Marzouqah S. Alanazi^f ; ^{Alanazima@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Saleh A. Aloqiel^g ; ^{aloqiels@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Ahmed M. Alenzi^h ; ^{alenezia@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Fahad Bafaqeehⁱ ; ^{bafaqeehf@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Amal M. Mohamed^j ; ^{mohameda@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Kamel Aldosari^k ; ^{aldosaryk@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author} ; Sameeh Ghazal^l ; ^{ghazals@pmah.med.sa" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Middle East Respirator Syndrome ; MERS-CoV ; Coronavirus ; Predictors ; Mortality
• 刊名：Travel Medicine and Infectious Disease
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：14
• 期：5
• 页码：464-470
• 全文大小：447 K

文摘

A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections.

Methods

Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory symptoms and tested negative for MERS-CoV on RT-PCR.

Results

None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%).

Conclusions

None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility.