Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling
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- 作者：Yi-Hsin Wanga ; Ke-Min Chenb ; Ping-Sung Chiub ; Shih-Chan Laib ; c ; Hsing-Hui Sud ; Ming-Shiou Jane ; f ; g ; Chia-Wei Line ; Dah-Yuu Luh ; i ; Yuan-Tsung Fuj ; k ; Jiuan-Miaw Liaol ; jmliao@csmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Jinghua Tsai Changa ; m ; jinghuat@csmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Shiang-Suo Huanga ; n ; o ; sshuang@csmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：I-R ; ischemia-reperfusion ; COX-2 ; cyclooxygenase-2 ; iNOS ; inducible nitric oxide synthase ; MMP-9 ; matrix metalloproteinase-9 ; TLR4 ; toll-like receptor 4 ; e-PA ; extrinsic plasminogen activator ; t-PA ; tissue plasminogen activator ; HR ; heart rate ; BP ; arterial blood pressure ; VPC ; ventricular premature complexes ; VT ; ventricular tachycardia ; VF ; ventricular fibrillation ; LDH ; lactate dehydrogenase ; MAPKs ; mitogen-activated protein kinases
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：113-122
- 全文大小：2008 K
文摘
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Lumbrokinase is a potent cardioprotective drug in rats subjected to myocardial I-R injury.
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Lumbrokinase protects myocardium against I-R injury via TLR4 signaling pathway.
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Lumbrokinase might be a potential therapeutic compound for treatment of acute myocardial infarction.