A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels
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- 作者：Milena B. Furtadoa ; i ; Julia C. Wilmannsa ; b ; Anjana Chandrana ; Mary Tontac ; Christine Bibend ; e ; Michael Eichenlauba ; Harold A. Colemanc ; Silke Bergera ; Romaric Bouveretf ; Reena Singhf ; Richard P. Harveyf ; Mirana Ramialisona ; James T. Pearsonc ; g ; Helena C. Parkingtonc ; Nadia A. Rosenthala ; h ; i ; Mauro W. Costaa ; i ; mauro.dacosta@monash.edu" class="auth_mail" title="E-mail the corresponding author ; mwcosta@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nkx2-5 ; Transcriptional regulation ; Ion channels
- 刊名：Differentiation
- 出版年：2016
- 出版时间：January-March 2016
- 年：2016
- 卷：91
- 期：1-3
- 页码：29-41
- 全文大小：3689 K
文摘
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A new Nkx2-5 conditional knockout mouse that fully deletes the gene was engineered.
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Adult Nkx2-5 heterozygous mice show mild morphological and functional dysfunction.
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Nkx2-5 regulates ion channels, including Kcnh2 isoform merg1b.
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Nkx2-5 mutations lead to decreased ERG (Kcnh2) channel activity.
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Nkx2-5 regulates genes associated with electric propagation in the heart.