Key cytokines of adaptive immunity are differentially induced in rainbow trout kidney by a group of structurally related geranyl aromatic derivatives
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- 作者：Beatriz Valenzuelaa ; beatriz.valenzuelam@usach.cl" class="auth_mail" title="E-mail the corresponding author ; Javiera Obrequea ; javiera.obreque@usach.cl" class="auth_mail" title="E-mail the corresponding author ; Sarita Soto-Aguileraa ; sarita.soto@usach.cl" class="auth_mail" title="E-mail the corresponding author ; Kevin Maiseya ; kevin.maisey@usach.cl" class="auth_mail" title="E-mail the corresponding author ; Mó ; nica Imaraia ; monica.imarai@usach.cl" class="auth_mail" title="E-mail the corresponding author ; Brenda Modakb ; brenda.modak@usach.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rainbow trout ; Immunostimulant activity ; Cytokines ; T and B cells ; Filifolinone ; Aromatic geranyl derivatives
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：49
- 期：Complete
- 页码：45-53
- 全文大小：1756 K
文摘
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3H-spiro 1-benzofuran-2,1′-cyclohexane derivatives of Heliotropium filifolium were studied.
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The structurally related terpenoid derivatives differentially induced trout cytokines.
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Activity is related to substitutions in cyclohexane C-7′ and benzene C-7 positions.
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Filifolinone is the most active immunostimulatory compound identified.
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Terpenoid derivatives can be used as immunostimulants or vaccine adjuvants.