Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity
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- 作者：K. Mahati1 ; V. Bhagya1 ; T. Christofer ; A. Sneha ; B.S. Shankaranarayana Rao ; bssrao.nimhans@gmail.com" class="auth_mail" title="E-mail the corresponding author ; bssrao100@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endogenous depression ; Neurodegeneration ; Learning and memory deficits ; Enriched environment ; Hippocampal synaptic plasticity ; Anxiety ; Hippocampal and amygdalar volumes
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：134
- 期：part_PB
- 页码：379-391
- 全文大小：2182 K
文摘
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Enrichment (EE) ameliorates impaired spatial learning and enhanced anxiety in depressed rats.
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EE restores depression-induced hippocampal atrophy and amygdalar hypertrophy.
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Impaired hippocampal synaptic plasticity in depression is restored by EE.
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EE could be a novel non-pharmacological tool to restore cognitive deficits in depression.