Possibilities in Germ Cell Research: An Engineering Insight

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• 作者：Fereshteh Esfandiari¹ ; ² ; Omid Mashinchian³ ; ⁴ ; Mohammad Kazemi Ashtiani¹ ; Mohammad Hossein Ghanian¹ ; Katsuhiko Hayashi⁵ ; Amir Ata Saei⁶ ; Morteza Mahmoudi⁷ ; ⁸ ; ⁹ ; Hossein Baharvand¹ ; ² ; ^{baharvand@royaninstitute.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：germ cells ; gametes ; pluripotent stem cells ; tissue engineering
• 刊名：Trends in Biotechnology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：33
• 期：12
• 页码：735-746
• 全文大小：3440 K

文摘

Germ cells (GCs) are responsible for fertility and disruptions in their development or function cause infertility. However, current knowledge about the diverse mechanisms involved in GC development and function is still in its infancy. This is mainly because there are low numbers of GCs, especially during embryonic development. A deeper understanding of GCs would enhance our ability to produce them from stem cells. In addition, such information would enable the production of healthy gametes for infertile couples. In this regard, pluripotent stem cells (PSCs) demonstrated a promising ability to produce GCs in vitro. In this review, we highlight recent advances in the field of tissue engineering that suggest novel strategies to enhance GC research.