Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease
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- 作者：Tiziana Bonifacinoa ; 1 ; bonifacino@difar.unige.it" class="auth_mail" title="E-mail the corresponding author ; Laura Musazzib ; 1 ; laura.musazzi@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Marco Milanesea ; milanese@difar.unige.it" class="auth_mail" title="E-mail the corresponding author ; Mara Seguinib ; mara.seguini@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Antonella Martec ; antonella.marte@unige.it" class="auth_mail" title="E-mail the corresponding author ; Elena Galliaa ; gallia@difar.unige.it" class="auth_mail" title="E-mail the corresponding author ; Luca Cattaneoa ; cattaneo@difar.unige.it" class="auth_mail" title="E-mail the corresponding author ; Franco Onofric ; franco.onofri@unige.it" class="auth_mail" title="E-mail the corresponding author ; Maurizio Popolib ; 1 ; maurizio.popoli@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Giambattista Bonannoa ; 1 ; bonanno@difar.unige.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：α/β-SNAP ; α/β soluble NSF attachment proteins ; ALS ; amyotrophic lateral sclerosis ; BoNt-C1 ; Botulinum Neurotoxin C1 ; β-Tub III ; β-Tubulin III ; [Ca2 ; +]c ; cytosolic calcium concentration ; CaMK-II ; Ca2 ; +/calmodulin-dependent protein kinase II ; dl-TBOA ; dl-threo-beta-benzyloxyaspartate ; GSK-3 ; glycogen synthase kinase 3 ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; [3H]D-Asp ; [3H]d-Aspartate ; mAbs ; monoclonal antibodies ; MNs ; motor neurons ; Munc-13 ; mammalian uncoordinated-13
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：122-133
- 全文大小：1245 K
文摘
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Glutamate release is excessive in the spinal cord of pre-symptomatic SOD1G93A mice.
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Assembly of SNARE complexes is fostered in pre-symptomatic SOD1G93A mice.
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Presynaptic protein expression and function are modified in SOD1G93A mice.
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The RRP of vesicles is enhanced in pre-symptomatic SOD1G93A mice.