Physico-chemical and mechanical characterization of in-situ forming xyloglucan gels incorporating a growth factor to promote cartilage reconstruction
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- 作者：Clelia Dispenzaa ; Simona Todaroa ; simona.todaro14@unipa.it" class="auth_mail" title="E-mail the corresponding author ; Donatella Buloneb ; Maria Antonietta Sabatinoa ; Giulio Ghersic ; Pier Luigi San Biagiob ; Caterina Lo Prestid
- 关键词：Cartilage reconstruction ; Injectable scaffolds ; In-situ forming gels ; Temperature-responsive ; Xyloglucan ; Growth factor
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：745-752
- 全文大小：1670 K
文摘
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In-situ forming gels incorporating a growth factor are formulated and characterized.
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The gel retains the growth factor and is colonized by chondrocytes.
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Mechanical properties and porosity of gels are controlled by polymer concentration.
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Incubation at 37 °C increases the gel strength and opens up the porous structure.