A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights
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- 作者：Chiara Parravicinia ; chiara.parravicini@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Simona Danielea ; b ; simona.daniele@for.unipi.it" class="auth_mail" title="E-mail the corresponding author ; Luca Palazzoloa ; luca.palazzolo@guest.unimi.it" class="auth_mail" title="E-mail the corresponding author ; Maria Letizia Trincavellib ; ltrincavelli@farm.unipi.it" class="auth_mail" title="E-mail the corresponding author ; Claudia Martinib ; claudia.martini@unipi.it" class="auth_mail" title="E-mail the corresponding author ; Paola Zaratinc ; paola.zaratin@aism.it" class="auth_mail" title="E-mail the corresponding author ; Roberto Primia ; roberto.primi@guest.unimi.it" class="auth_mail" title="E-mail the corresponding author ; Giusy Coppolinoa ; giusy.coppolino@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Elisabetta Gianazzaa ; elisabetta.gianazza@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Maria P. Abbracchioa ; mariapia.abbracchio@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Ivano Eberinia ; d ; ivano.eberini@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：SDF-1 ; stromal cell-derived factor 1 ; GPCR ; G protein-coupled receptor ; CNS ; central nervous system ; NS ; nervous system ; DRG ; dorsal root ganglion ; OPC ; oligodendrocyte precursor cell ; MS ; multiple sclerosis ; PDB ; Protein Data Bank ; TM ; transmembrane ; EL ; extracellular loop ; IL ; intracellular loop ; NT ; N-terminus ; SD ; steepest descend ; CG ; conjugate gradient ; TN ; truncated Newton ; EM ; energy minimization ; GBSW ; Generalized Born with a simple switching ; ABNR ; adopted basis Newton&ndash ; Raphson ; R
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：28
- 期：6
- 页码：631-642
- 全文大小：2175 K
文摘
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GPR17 is a promiscuous class-A GPCR operated by different ligand families.
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The chemokine receptor ligand SDF-1 interacts with GPR17 via an extended network.
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SDF-1 binding to GPR17 activates intracellular heterotrimeric Gi protein pathway.
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GPR17 activation by SDF-1 promotes maturation of oligodendrocyte precursor cells.
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Cangrelor competitively antagonizes SDF-1 activation of GPR17.