Antinociceptive effect of intrathecal amiloride on neuropathic pain in rats
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- 作者：Peizong Wanga ; 1 ; Handong Ouyanga ; 1 ; Qiang Lia ; Lei Haob ; Yang Huanga ; Weian Zenga ; zengwa@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuropathic pain ; Amiloride ; c-Fos ; p38 MAPK
- 刊名：Neuroscience Letters
- 出版年：2015
- 出版时间：14 September 2015
- 年：2015
- 卷：604
- 期：Complete
- 页码：24-29
- 全文大小：766 K
文摘
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Intrathecal amiloride can produce the antinociception on neuropathic pain.
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The antinociception is dose- and time-dependent.
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Amiloride inhibits c-Fos and p-p38 MAPK in the spinal dorsal horn.
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The effect of amiloride is through inhibiting neurons and microglia activation.